Anti Beta 2 Glikoprotein 1 Antikoru

Anti beta 2 glikoprotein 1 antikoru beta 2 glikoprotein 1 antijenine karşı oluşmaktadır. Görevi fosfolipit ve beta 2 glikoprotein 1 kompleksini yıkmaktır. Vücudun kendi kendine savaş açtığı bu durum antifosfolipit adı verilen otoimmün bir hastalığı meydana getirmektedir. Bu hastalık özellikle genç yaşlardaki kadınlarda düşük riskini ve erken doğumları arttırmaktadır. Trombotik bir olayı düşündüren ellerde ve ayaklarda şişlik, nefes darlığı ve baş ağrısında antifosfolipit antikor testi istenir.
Beta 2 Glikoprotein 1 Nedir ?
Beta 2 glikoprotein 1 ; hepatositler, endotel hücreler ve trofoblast hücreleri tarafından sentezlenen 5 bölge ve toplam 60 aminoasitten oluşan bir yapıdır. Beta 2 glikoprotein 1 ‘in hücre membranında bulunan fosfolipitler ile yaptığı kompleksler antifosfolipit antikorlarının (anti beta 2 glikorotein 1 antikoru ) hedefini teşkil eder. Beta 2 glikoprotein 1 ‘e karşı yapılan antikor testinin pozitif sonuç vermesi antifosfolipit sendromda kullanılan labaratuvar bulgularının başında gelmektedir. Diğer bulgular IgM, IgI ve lupus antikoagülan varlığıdır.
Antifosfolipit ( anti beta 2 glikoprotein 1 antikoru ) sendromu genellikle genç yaştaki kadınlarda sıklıkla görülmektedir. Bu antikorun varlığı genç yaştaki kadınlarda venlerde ve arterlerde herhangi bir inflamasyon kaynağı olmaksızın pıhtılaşmaya sebep olmaktadır. Bu pıhtılaşma sonucu kadınlarda sıklıkla düşük görülmektedir. Anti beta 2 glikoprotein 1 antikoru sendromu otoimmün bir hastalıktır. Bazı kişilerde hastalık hiçbir belirti göstermeden varlığını sürdürebilmektedir. Ancak gerekli testler yapıldığında hastalık ortaya çıkmaktadır.
Beta 2 Glikoprotein 1 Yüksekliği
Antifosfolipit sendromunun konulabilmesi için beta 2 glikoprotein 1 yüksekliği belirleyici bir unsurdur. Ancak kesin sonuç için 12 hafta aralıklı yapılan iki testte de anti beta 2 glikoprotein 1 antikoru, antifosfolipit antikorları ve lupus antikoagülan testlerinden en az biri pozitif olmalı ayrıca bu testlere tekrarlayan tromboz, düşük ve trombosit sayısı düşüklüğü eşlik etmelidir. Bu gibi sıklıkla karşılaşılan pıhtılaşma problemlerinde, düşük trombosit sayısında ve erken doğum ya da düşüklerde mutlaka doktorunuza başvurarak anti beta 2 glikoprotein 1 antikoru değerinizi kontrol ettiriniz.
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